Dokter Anakku

THYROID STIMULATING HORMON AND SEXUAL MATURITY IN DOWN SYNDROME

Already Presented at 14th KONIKA, Surabaya, July 2008

THE RELATIONSHIP BETWEEN INCREASING OF THYROID STIMULATING HORMON (TSH) AND SEXUAL MATURITY IN DOWN SYNDROME

Vicka Farah Diba, S.Yudha Patria, Madarina Julia.

Pediatric Health Department,
Medical Faculty, Gadjah Mada University – RS Sardjito
Yogyakarta.

Background : Abnormality in 21st chromosome may influence to almost all internal organ and related to systemic disease such as heart disease, endocrine and extremity. Congenital hypothyroid prevalence in Down Syndrome 28 times more than normal population, some conditions that related to hypothyroidism such as diabetes mellitus, dementia and premature puberty. Based on theory, premature puberty is a result from the presence of sub unit TSH alpha that identically to CI LH, can cause cross reaction with FSH, LH and the activation of TSH at FSH-R cause gonad stimulation.

Objective : To study the association between increasing of TSH level and sexual maturity in Down syndrome

Methode : A cross sectional study was conducted at Kotamadya Yogyakarta in March 2008. We examined sexual maturity of Down syndrome child, aged 8 – 18 years and took blood sample for the value of TSH serum level. Down syndrome diagnosis established from clinical feature, sexual maturity examination based on Tanner sexual maturity stage and TSH serum level examined in laboratory. The association between increasing of TSH serum level and sexual maturity stage will be analyzed with chi square test.

Results: At preliminary research we found 23 Down syndrome child (15 girls and 8 boys) the laboratory results showed 21 children had normal TSH level and two children had increased TSH level ( > 4,94 IU/mmol) and the examination showed their sexual maturity match with their age according to Tanner stage.

Conclusion : We haven’t find early sexual maturity at increasing TSH level